The Hamilton Morris Podcast
Hamilton Morris creates and shares content with his followers on Patreon. These podcasts are released on this platform and on Youtube after first being posted on Patreon for a month or longer. The free versions of these conversations are made, in part, with the help of Hamilton's sponsors. Hope you enjoy!
The Hamilton Morris Podcast
Discovering Ketamine with Dr. Edward Domino
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In this episode I sit down the arylcyclohexylamine legend Dr. Edward F. Domino to discuss his pioneering research on ketamine, his subsequent research on NMDA antagonists, and his first encounter with a patient who reported antidepressant activity from using ketamine.
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0:00 Introduction & context
2:45 The discovery of ketamine
8:30 Phencyclidine derivatives & Parke-Davis
14:15 First human administration of ketamine
19:30 The testicle compression experiment
23:45 Initial impressions & anesthetic potential
28:15 Collaboration with psychiatrists at Lafayette Clinic
32:00 Ketamine as a model for schizophrenia
36:30 The missed antidepressant discovery
42:15 The patient who knew better
46:45 Regret & listening to patients
51:00 FDA approval & antidepressant recognition
55:30 John C. Lilly & Marsha Moore
59:00 R-ketamine vs S-ketamine
63:45 The right-hand form & less dissociation
68:30 The Cal Stevens patent scandal
74:00 Cal Stevens the medicinal chemist
79:00 A missed opportunity to meet Cal Stevens
83:15 The endogenous ligand question
87:45 Complex mechanisms of ketamine action
92:00 Sigma receptors & research opportunities
96:30 R-ketamine as the future direction
101:00 Career advice & getting funded
105:30 The importance of permission from your boss
109:15 LSD-25 & other opportunities
112:45 Final reflections on legacy & family